Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.57 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.57 |
| ▸ | CASR | P41180 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29411940 | 1.00 | CYP11B2 (0.58) | CYP11B2ALDH1A1PDE6DALDH2ALDH3A1 | |
| SCHEMBL29411897 | 0.88 | ALDH1A1 (0.76) | CYP11B2ALDH1A1PDE6DALDH2ALDH3A1 | |
| SCHEMBL15314762 | 0.87 | ALDH1A1 (0.73) | ALDH1A1PDE6DALDH2ALDH3A1CASR | |
| SCHEMBL29411911 | 0.87 | ALDH1A1 (0.73) | ALDH1A1PDE6DALDH2ALDH3A1CASR | |
| SCHEMBL12467962 | 0.85 | CYP11B2 (0.54) | CYP11B2ALDH1A1PDE6DALDH2ALDH3A1 | |
| SCHEMBL29411929 | 0.85 | ALDH1A1 (0.61) | ALDH1A1PDE6DALDH2ALDH3A1CASR | |
| SCHEMBL12116699 | 0.82 | CYP11B2 (0.70) | CYP11B2ALDH1A1PDE6DALDH2ALDH3A1 | |
| SCHEMBL15567817 | 0.80 | TP53 (0.78) | ALDH1A1PDE6DALDH2ALDH3A1CASR | |
| SCHEMBL29412072 | 0.80 | TP53 (0.78) | ALDH1A1PDE6DALDH2ALDH3A1CASR | |
| SCHEMBL29411938 | 0.79 | TP53 (0.68) | ALDH1A1PDE6DALDH2ALDH3A1CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978301-B | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2022-08-02 | — | — | CN | disclosed |
| CN-111978301-A | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2020-11-24 | — | — | CN | disclosed |