SCHEMBL31440788

SCHEMBL31440788

COc1ccc(C(F)(F)F)cc1NC(=O)Nc1cc(C(F)(F)F)ccc1OC

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.61
MEN1 O00255 1/20 0.61
MAPT P10636 4/20 0.59
KDM4E B2RXH2 3/20 0.59
RAF1 P04049 7/20 0.58
CYP1A2 P05177 2/20 0.57
CYP2C9 P11712 2/20 0.57
CYP2C19 P33261 2/20 0.57
MAPK14 Q16539 1/20 0.56
HTT P42858 3/20 0.56
BRAF P15056 1/20 0.54
MAPK1 P28482 1/20 0.54
CYP3A4 P08684 1/20 0.53
POLB P06746 1/20 0.53
ALDH1A1 P00352 1/20 0.52
HPGD P15428 1/20 0.52
LMNA P02545 1/20 0.52
HSP90AA1 P07900 1/20 0.52
RECQL P46063 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30667490 0.89 RAB9A (0.59) KMT2AMEN1MAPTKDM4ERAF1
SCHEMBL8370028 0.89 GRIK1 (0.65) KMT2AMEN1MAPTRAF1HTT
SCHEMBL4247303 0.89 MEN1 (0.64) KMT2AMEN1MAPTKDM4ERAF1
SCHEMBL379862 0.89 RAB9A (0.59) KMT2AMEN1MAPTKDM4ERAF1
SCHEMBL4243486 0.89 RAF1 (0.61) KMT2AMEN1MAPTRAF1HTT
SCHEMBL3476076 0.89 RAF1 (0.61) KMT2AMEN1MAPTRAF1HTT
SCHEMBL1463353 0.89 MAPK14 (0.57) KMT2AMEN1MAPTKDM4ERAF1
SCHEMBL13170085 0.89 CYP1A2 (0.72) KMT2AMEN1MAPTKDM4ERAF1
SCHEMBL20357363 0.89 MAPT (0.58) KMT2AMEN1MAPTKDM4ERAF1
SCHEMBL5445313 0.88 RAF1 (0.60) KMT2AMEN1MAPTRAF1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119390612-A Preparation method and application of 1, 3-bis (2-methoxy-5- (trifluoromethyl) phenyl) urea 上海泰坦科技股份有限公司 2025-02-07 CN claimed
CN-119390612-A Preparation method and application of 1, 3-bis (2-methoxy-5- (trifluoromethyl) phenyl) urea 上海泰坦科技股份有限公司 2025-02-07 CN disclosed
CN-119390612-A Preparation method and application of 1, 3-bis (2-methoxy-5- (trifluoromethyl) phenyl) urea 上海泰坦科技股份有限公司 2025-02-07 CN disclosed
CN-119390612-A Preparation method and application of 1, 3-bis (2-methoxy-5- (trifluoromethyl) phenyl) urea 上海泰坦科技股份有限公司 2025-02-07 CN disclosed