Isolithocholic Acid

Isolithocholic Acid

SCHEMBL289049

C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 7/20 1.00
EPHA2 P29317 4/20 1.00
CASP7 P55210 3/20 1.00
VDR P11473 3/20 1.00
HIF1A Q16665 3/20 1.00
TP53 P04637 2/20 1.00
MAPK1 P28482 2/20 1.00
HSD17B10 Q99714 2/20 1.00
BLM P54132 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
USP2 O75604 2/20 1.00
CYP3A4 P08684 2/20 1.00
NR1H4 Q96RI1 2/20 1.00
LMNA P02545 2/20 1.00
MDM4 O15151 1/20 1.00
MAPT P10636 1/20 1.00
HSPD1 P10809 1/20 1.00
TSHR P16473 1/20 1.00
PTPN2 P17706 1/20 1.00
PTPN1 P18031 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lithocholic Acid SCHEMBL22756077 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22894393 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22871939 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22079173 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL24001494 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22894425 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL23923735 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL24001453 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL24567422 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22415871 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 169 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3869192-B1 METHOD FOR QUANTITATIVE DETECTION OF VARIOUS METABOLITES IN BIOLOGICAL SAMPLE HUMAN METABOLOMICS INST INC (CN) 2026-05-13 EP claimed
US-20260085364-A1 USE OF BIOMARKERS IN TREATMENT WITH BIFIDOBACTERIA INT N&H DENMARK APS (DK) 2026-03-26 US claimed
EP-4702980-A1 ISOLITHOCHOLIC ACID FOR USE IN THE PREVENTION OR TREATMENT OF INFLAMMATORY DISEASES OF THE RESPIRATORY SYSTEM Instytut Biologii Doswiadczalnej PAN. im. M. Nenckiego (PL) 2026-03-04 EP claimed
US-20250258146-A1 QUANTITATIVE DETECTION METHOD OF MULTIPLE METABOLITES IN BIOLOGICAL SAMPLE AND METABOLIC CHIP HUMAN METABOLOMICS INSTITUTE INC. (CN) 2025-08-14 US claimed
EP-4591065-A1 USE OF BIOMARKERS IN TREATMENT WITH BIFIDOBACTERIA International N&H Denmark ApS (DK) 2025-07-30 EP claimed
WO-2025128875-A1 COMPOSITIONS, KITS, AND METHODS FOR ASSESSING MICROBIOME HEALTH THE UNIVERSITY OF CHICAGO (US) 2025-06-19 WO claimed
CN-119923565-A Use of biomarkers in treatment with bifidobacteria 国际N&H丹麦有限公司 2025-05-02 CN claimed
US-20240342201-A1 ASYMMETRIC GPR84 ANTAGONIST AND USE THEREOF SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2024-10-17 US claimed
CN-117630240-B Extraction and quantitative detection method of 87 bile acids in feces and intestinal contents 浙江大学 2024-09-03 CN claimed
CN-118566493-A Preparation method of blood reference product applied to next generation metabonomics 上海阿趣生物科技有限公司 2024-08-30 CN claimed
WO-2022132678-A1 BIOLOGICAL DELIVERY SYSTEMS DNALITE THERAPEUTICS, INC. (US) 2022-06-23 WO claimed
EP-3982932-A1 COMPOSITIONS AND METHODS FOR BIOLOGICAL DELIVERY VEHICLES Dnalite Therapeutics, Inc. (US) 2022-04-20 EP claimed
US-20220026398-A1 QUANTITATIVE DETECTION METHOD OF MULTIPLE METABOLITES IN BIOLOGICAL SAMPLE AND METABOLIC CHIP HUMAN METABOLOMICS INSTITUTE INC. (CN) 2022-01-27 US claimed
EP-3875596-A1 METHOD FOR HYDROXYLATION OF STEROIDS Pharmazell GmbH (DE) 2021-09-08 EP claimed
EP-3875597-A1 METHOD FOR HYDROXYLATION OF STEROIDS Annikki GmbH (AT) 2021-09-08 EP claimed
US-20210148893-A1 METHOD FOR DETERMINING IN VITRO BIOEQUIVALENCE OF A SUCRALFATE SUSPENSION SAMPLE TO A SUCRALFATE SUSPENSION REFERENCE LISTED DRUG (RLD) CLAYTON PHARMACEUTICALS LLC (US) 2021-05-20 US claimed
EP-3423829-B1 METHOD FOR DETERMINING IN VITRO BIOEQUIVALENCE OF A SUCRALFATE SUSPENSION SAMPLE TO A SUCRALFATE SUSPENSION REFERENCE LISTED DRUG (RLD) CLAYTON PHARMACEUTICALS LLC (US) 2020-10-28 EP claimed
EP-3423829-A1 METHOD FOR DETERMININGIN VITRO Clayton Pharmaceuticals LLC (US) 2019-01-09 EP claimed
WO-2018204894-A1 METHOD FOR DETERMINING IN VITRO BIOEQUIVALENCE OF A SUCRALFATE SUSPENSION SAMPLE TO A SUCRALFATE SUSPENSION REFERENCE LISTED DRUG (RLD) CLAYTON PHARMACEUTICALS LLC (US) 2018-11-08 WO claimed
US-9989519-B1 Method for determining in vitro bioequivalence of a sucralfate suspension sample to a sucralfate suspension reference listed drug (RLD) Clayton Pharmaceuticals, LLC (US) 2018-06-05 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240342201-A1 ASYMMETRIC GPR84 ANTAGONIST AND USE THEREOF GPR84, GPR65, GPR88 GPBAR1 24/4885EPHA2 1448/4885CASP7 2556/4885
US-20260085364-A1 USE OF BIOMARKERS IN TREATMENT WITH BIFIDOBACTERIA FABP2, ALPI, CES1 GPBAR1 58/4885EPHA2 760/4885CASP7 2164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.