SCHEMBL28906141

SCHEMBL28906141

O=c1c(N2CCOCC2)noc2ccccc12

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.58
KDM4E B2RXH2 3/20 0.58
PRKDC P78527 3/20 0.51
ACE P12821 1/20 0.51
ECE1 P42892 1/20 0.51
MAPT P10636 1/20 0.48
PTK2 Q05397 1/20 0.47
POLB P06746 1/20 0.46
LMNA P02545 1/20 0.45
MAPK1 P28482 1/20 0.45
HPGD P15428 2/20 0.44
GLA P06280 1/20 0.44
GAA P10253 1/20 0.44
HTR1A P08908 2/20 0.44
HTR2A P28223 2/20 0.44
ELANE P08246 1/20 0.43
XRCC6 P12956 1/20 0.43
XRCC5 P13010 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5568459 0.75 HTR1A (0.49) HTR1AHTR2A
Hydrochloric Acid SCHEMBL5567668 0.74 HTR1A (0.48) HTR1AHTR2A
SCHEMBL9377818 0.74 HPGD (0.55) ALDH1A1KDM4EMAPTMAPK1HPGD
SCHEMBL458698 0.72 HPGD (0.58) KDM4EMAPK1HPGDGLAGAA
SCHEMBL3236794 0.71 SORD (0.51) HTR1AHTR2A
SCHEMBL194219 0.70 HTR2C (0.50) KDM4EMAPT
SCHEMBL14046594 0.70 SORD (0.54) HTR1AHTR2A
Hydrochloric Acid SCHEMBL6219759 0.69 KDM4E (0.51) ALDH1A1KDM4EMAPTLMNAHPGD
SCHEMBL7328899 0.69 PRKDC (0.54) ALDH1A1KDM4EPRKDCACEECE1
SCHEMBL7320806 0.69 PRKDC (0.54) ALDH1A1KDM4EPRKDCACEECE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115109006-A 3-substituted-1, 2-benzoxazine-4-ketone compound and preparation method thereof 上海大学 2022-09-27 CN disclosed