Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.49 |
| ▸ | HTR2A | P28223 | 12/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | SORD | Q00796 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5567668 | 0.98 | HTR1A (0.48) | HTR1AHTR2ADRD2SORD | |
| SCHEMBL9377818 | 0.83 | HPGD (0.55) | HTR1AHTR2ADRD2SORD | |
| SCHEMBL458698 | 0.81 | HPGD (0.58) | HTR1AHTR2ADRD2SORD | |
| SCHEMBL3236794 | 0.80 | SORD (0.51) | HTR1AHTR2ADRD2SORD | |
| SCHEMBL194219 | 0.79 | HTR2C (0.50) | DRD2SORD | |
| SCHEMBL14046594 | 0.79 | SORD (0.54) | HTR1AHTR2ADRD2SORD | |
| Hydrochloric Acid SCHEMBL6219759 | 0.77 | KDM4E (0.51) | DRD2SORD | |
| SCHEMBL23064355 | 0.76 | HTR2A (0.48) | HTR1AHTR2ADRD2SORD | |
| SCHEMBL30778007 | 0.75 | SORD (0.50) | HTR1AHTR2ADRD2SORD | |
| SCHEMBL28906141 | 0.75 | ALDH1A1 (0.58) | HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054885-B1 | BENZISOXAZOLE DERIVATIVES HAVING D4-ANTAGONISTIC ACTIVITY | DUPHAR INT RES (NL) | 2007-07-18 | — | — | EP | disclosed |
| US-6335326-B1 | DOPAMINE AGONIST AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; ANXIOLYTIC, ANTIDEPRESSANT AND ANTIISCHEMIC AGENTS; PARKINSON*S DISEASE | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2002-01-01 | — | — | US | disclosed |
| EP-1054885-A2 | BENZISOXAZOLE DERIVATIVES HAVING D4-ANTAGONISTIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040067-A2 | BENZISOXAZOLE DERIVATIVES HAVING D4-ANTAGONISTIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1999-08-12 | — | — | WO | disclosed |