Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 7/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28906191 | 0.82 | LMNA (0.41) | LMNANOTUMAKR1C3MEN1KMT2A | |
| SCHEMBL25045436 | 0.73 | LMNA (0.45) | LMNAPTGER4MAPTALDH1A1 | |
| SCHEMBL25045051 | 0.71 | PTGER4 (0.37) | LMNAPTGER4MAPT | |
| SCHEMBL14736717 | 0.70 | LMNA (0.49) | LMNAMAPK1ALDH1A1 | |
| SCHEMBL28906211 | 0.70 | IKBKE (0.41) | LMNAPTGER4AKR1C3MEN1KMT2A | |
| SCHEMBL2688524 | 0.66 | TSHR (0.41) | LMNAMAPK1ALDH1A1 | |
| SCHEMBL23856156 | 0.65 | MAOB (0.39) | LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL14736718 | 0.65 | NPC1 (0.50) | LMNA | |
| SCHEMBL26097267 | 0.63 | CYP1A2 (0.35) | LMNANOTUMALDH1A1 | |
| SCHEMBL27849054 | 0.61 | CYP1A2 (0.56) | PTGER4AKR1C3MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149933-A1 | NEW TRIAZOLYL DERIVATIVES AS GABA A ALPHA5 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-22 | — | — | EP | disclosed |
| CN-115461337-A | Novel triazolyl derivatives as GABA A alpha 5 PAM | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | disclosed |