Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16013442 | 0.75 | KDM4E (0.51) | TSHRKDM4ELMNARECQLPOLB | |
| SCHEMBL21333004 | 0.70 | TSHR (0.46) | TSHRKDM4ELMNARECQLPOLB | |
| SCHEMBL30285637 | 0.70 | TSHR (0.46) | TSHRKDM4ELMNARECQLPOLB | |
| SCHEMBL3614141 | 0.70 | TDP1 (0.54) | TSHRPOLBMAPTGAAALDH1A1 | |
| SCHEMBL22413013 | 0.69 | POLB (0.41) | TSHRKDM4ELMNARECQLPOLB | |
| SCHEMBL29863299 | 0.69 | POLB (0.41) | TSHRKDM4ELMNARECQLPOLB | |
| SCHEMBL13547186 | 0.68 | ALDH1A1 (0.49) | TSHRKDM4ELMNARECQLPOLB | |
| SCHEMBL28853322 | 0.67 | LPAR1 (0.56) | TSHRKDM4ELMNARECQLPOLB | |
| SCHEMBL30301453 | 0.67 | PRKACA (0.44) | TSHRMAPTSLC2A1PIK3R1PIK3CA | |
| SCHEMBL13319148 | 0.67 | TSPO (0.51) | TSHRKDM4EPOLBMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115433211-A | Pyrazidopyridone methionine adenosyltransferase 2A inhibitors | 南京正大天晴制药有限公司 | 2022-12-06 | — | — | CN | disclosed |