Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | PRKACG | P22612 | 1/20 | 0.40 |
| ▸ | PRKACB | P22694 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22413013 | 1.00 | POLB (0.41) | POLBGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL14136869 | 0.71 | ALDH1A1 (0.47) | POLBGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL3614141 | 0.70 | TDP1 (0.54) | POLBGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL30301447 | 0.69 | ALDH1A1 (0.38) | ALDH1A1NPSR1PRKACAPRKACGPRKACB | |
| SCHEMBL28906249 | 0.69 | TSHR (0.46) | POLBGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL14154861 | 0.69 | ALDH1A1 (0.64) | POLBGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL13547186 | 0.68 | ALDH1A1 (0.49) | POLBGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL28853322 | 0.68 | LPAR1 (0.56) | POLBGAAMAPTALDH1A1LPAR1 | |
| SCHEMBL13319148 | 0.67 | TSPO (0.51) | POLBGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL30597441 | 0.66 | CSNK2A2 (0.41) | GAAPRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901279-A | Inhibitors of cGAS for the treatment of autoinflammatory diseases and cancer metastasis | 洛克菲勒大学 | 2022-08-12 | — | — | CN | disclosed |