Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31243002 | 1.00 | CYP3A4 (0.39) | CYP3A4ALDH1A1GAAMAPTTHRB | |
| SCHEMBL15544603 | 0.85 | CYP3A4 (0.48) | CYP3A4ALDH1A1GAATHRBTSHR | |
| SCHEMBL23043132 | 0.76 | HSD17B10 (0.39) | CYP3A4HTT | |
| SCHEMBL25533309 | 0.76 | KMT2A (0.35) | ALDH1A1GAA | |
| SCHEMBL23174552 | 0.76 | GAA (0.39) | GAAMAPT | |
| SCHEMBL29679938 | 0.76 | HSD17B10 (0.39) | CYP3A4HTT | |
| SCHEMBL28920148 | 0.73 | MAPT (0.37) | ALDH1A1GAAMAPTHTT | |
| SCHEMBL26207348 | 0.73 | MAOA (0.37) | ALDH1A1 | |
| SCHEMBL3823135 | 0.73 | KDM1A (0.38) | CYP3A4ALDH1A1 | |
| SCHEMBL31527534 | 0.72 | ALDH1A1 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4713330-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF | HUTCHMED Limited (CN) | 2026-03-25 | — | — | EP | disclosed |
| WO-2024235286-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF | HUTCHMED LIMITED (CN) | 2024-11-21 | — | — | WO | disclosed |
| CN-115490709-A | KRASG12D inhibitor and application thereof in medicine | 四川海思科制药有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-115304623-A | Pyrimido-cyclic derivative and application thereof in medicine | 四川海思科制药有限公司 | 2022-11-08 | — | — | CN | disclosed |