Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17642593 | 0.85 | AKR1C3 (0.42) | LMNAPDK1MTORCYP2C9CYP2C19 | |
| SCHEMBL17642602 | 0.85 | AKR1C3 (0.42) | LMNAPDK1MTORCYP2C9CYP2C19 | |
| SCHEMBL15651450 | 0.84 | MTOR (0.41) | PDK1MTORFPR2SCN9APIK3R1 | |
| SCHEMBL2477443 | 0.84 | PDK1 (0.40) | PDK1MTORPIK3C3FPR2SCN9A | |
| SCHEMBL13735239 | 0.84 | MTOR (0.41) | PDK1MTORFPR2SCN9APIK3R1 | |
| SCHEMBL20878004 | 0.84 | PDK1 (0.40) | PDK1MTORPIK3C3FPR2SCN9A | |
| SCHEMBL19314154 | 0.83 | LMNA (0.43) | LMNAMTORPIK3C3SLC6A2SLC6A4 | |
| SCHEMBL20457915 | 0.81 | FKBP1A (0.44) | LMNAPDK1MTORFPR2SCN9A | |
| SCHEMBL20457943 | 0.81 | FKBP1A (0.44) | LMNAPDK1MTORFPR2SCN9A | |
| SCHEMBL17660617 | 0.80 | FKBP1A (0.45) | LMNAPDK1MTORMAPK1PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285850-B | Isoindoline compounds, preparation method thereof, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2022-04-22 | — | — | CN | disclosed |