SCHEMBL28910085

SCHEMBL28910085

O=[PH]1c2ccccc2-c2c(F)cccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 2/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
AKR1A1 P14550 1/20 0.35
AKR1B1 P15121 1/20 0.35
TTR P02766 1/20 0.32
NFE2L2 Q16236 1/20 0.31
CES2 O00748 2/20 0.31
CES1 P23141 2/20 0.31
DDB1 Q16531 1/20 0.31
CRBN Q96SW2 1/20 0.31
SMARCA2 P51531 1/20 0.31
SMARCA4 P51532 1/20 0.31
PBRM1 Q86U86 1/20 0.31
PTPRC P08575 1/20 0.31
PTPN1 P18031 1/20 0.31
MEN1 O00255 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3925080 0.75 MEN1 (0.40) CA1CA2CA7CA9CES2
SCHEMBL19452869 0.73 MEN1 (0.43) CA1CA2CA7CA9CES2
SCHEMBL22129686 0.67 CA1 (0.48) PDK2CA1CA2CA7CA9
SCHEMBL6655232 0.66 PDK2 (0.44) PDK2CA1CA2CA7CA9
SCHEMBL29450773 0.66 S100A4 (0.42) CA1CA2CA7CA9CES2
SCHEMBL2278368 0.66 S100A4 (0.42) CA1CA2CA7CA9CES2
SCHEMBL21257652 0.64 DNMT1 (0.53) CES1MEN1MAPTKMT2A
SCHEMBL5866470 0.64 CA1 (0.52) PDK2CA1CA2CA7CA9
SCHEMBL13487412 0.64 CA1 (0.52) PDK2CA1CA2CA7CA9
SCHEMBL10716838 0.64 MAOA (0.52) CA1CA2CA7CA9AKR1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115477674-A Organophosphorus compounds based on phosphafluorene structural units and preparation method thereof 北京大学 2022-12-16 CN disclosed