SCHEMBL28910656

SCHEMBL28910656

N#Cc1ccccc1C(Br)CBr

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
TSHR P16473 2/20 0.39
KDM4E B2RXH2 1/20 0.34
HPGD P15428 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CYP19A1 P11511 1/20 0.34
TRPA1 O75762 1/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
SGMS2 Q8NHU3 1/20 0.33
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
USP8 P40818 1/20 0.32
USP7 Q93009 1/20 0.32
ESR2 Q92731 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7412886 0.82 TSHR (0.42) ALDH1A1L3MBTL1TSHRKDM4EHPGD
SCHEMBL11414735 0.79 TSHR (0.44) ALDH1A1L3MBTL1TSHRKDM4EHPGD
SCHEMBL11613250 0.79 TSHR (0.44) ALDH1A1L3MBTL1TSHRKDM4EHPGD
SCHEMBL30276914 0.78 ALDH1A1 (0.37) ALDH1A1TSHRTRPA1CYP1A2CYP2C9
SCHEMBL8683054 0.78 ALDH1A1 (0.37) ALDH1A1TSHRTRPA1CYP1A2CYP2C9
SCHEMBL29974545 0.75 TSHR (0.46) ALDH1A1L3MBTL1TSHRKDM4EHPGD
SCHEMBL507010 0.75 TSHR (0.46) ALDH1A1L3MBTL1TSHRKDM4EHPGD
SCHEMBL1125095 0.75 TRPA1 (0.50) ALDH1A1L3MBTL1TSHRKDM4EHPGD
SCHEMBL4078370 0.73 TSHR (0.48) ALDH1A1L3MBTL1TSHRKDM4EHPGD
SCHEMBL30759997 0.72 TRPA1 (0.47) ALDH1A1L3MBTL1TSHRKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110862292-B Preparation method of 1-aryl-1, 2-dibromoethane 中国科学院兰州化学物理研究所 2021-04-06 CN disclosed
CN-110862292-A Preparation method of 1-aryl-1, 2-dibromoethane 中国科学院兰州化学物理研究所 2020-03-06 CN disclosed