Sugi Predict

Sugi Predict / Compounds / SCHEMBL507010

SCHEMBL507010

SCHEMBL507010

CC(Br)c1ccccc1C#N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.46
▸ ALDH1A1 P00352 5/20 0.45
▸ L3MBTL1 Q9Y468 2/20 0.45
▸ HPGD P15428 2/20 0.37
▸ HTT P42858 1/20 0.36
▸ TRPA1 O75762 1/20 0.35
▸ P2RX7 Q99572 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ AR P10275 1/20 0.35
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ USP8 P40818 1/20 0.34
▸ USP7 Q93009 1/20 0.34
▸ ESR2 Q92731 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ IMPDH2 P12268 1/20 0.33
▸ KCNA5 P22460 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29974545 1.00 TSHR (0.46) TSHRALDH1A1L3MBTL1HPGDHTT
SCHEMBL8390663 0.83 TSHR (0.46) TSHRALDH1A1L3MBTL1HPGDHTT
SCHEMBL29835035 0.82 TSHR (0.50) TSHRALDH1A1L3MBTL1HPGDHTT
SCHEMBL11613250 0.82 TSHR (0.44) TSHRALDH1A1L3MBTL1HPGDHTT
SCHEMBL11414735 0.82 TSHR (0.44) TSHRALDH1A1L3MBTL1HPGDHTT
SCHEMBL254017 0.82 TSHR (0.50) TSHRALDH1A1L3MBTL1HPGDHTT
SCHEMBL30762168 0.80 P2RX7 (0.39) TSHRALDH1A1L3MBTL1HPGDP2RX7
SCHEMBL28797368 0.80 P2RX7 (0.39) TSHRALDH1A1L3MBTL1HPGDP2RX7
Ethane SCHEMBL2154170 0.80 TSHR (0.48) TSHRALDH1A1L3MBTL1HPGDHTT
SCHEMBL20356776 0.80 TSHR (0.48) TSHRALDH1A1L3MBTL1HPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260000642-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS TAY THERAPEUTICS LTD (GB) 2026-01-01 — — US disclosed
US-20250263370-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS Tay Therapeutics Limited (GB) 2025-08-21 — — US disclosed
EP-4558224-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS Tay Therapeutics Limited (GB) 2025-05-28 — — EP disclosed
WO-2024018423-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS Tay Therapeutics Limited (GB) 2024-01-25 — — WO disclosed
WO-2020243135-A1 FUSED HETEROCYCLIC DERIVATIVES Janssen Sciences Ireland Unlimited Company (IE) 2020-12-03 — — WO disclosed
US-10829480-B2 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives GRUENENTHAL GMBH (DE) 2020-11-10 — — US disclosed
US-9980952-B2 Modulators of methyl modifying enzymes, compositions and uses thereof CONSTELLATION PHARMACEUTICALS, INC. (US) 2018-05-29 — — US disclosed
US-9980952-B2 Modulators of methyl modifying enzymes, compositions and uses thereof CONSTELLATION PHARMACEUTICALS, INC. (US) 2018-05-29 — — US disclosed
US-9980952-B2 Modulators of methyl modifying enzymes, compositions and uses thereof CONSTELLATION PHARMACEUTICALS, INC. (US) 2018-05-29 — — US disclosed
US-20170312262-A9 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. (US) 2017-11-02 — — US disclosed
WO-2005082859-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2005-09-09 — — WO disclosed
CN-1050129-C Bicyclic tetrahydro pyrazolopyridines and their use as medicaments PFIZER (US) 2000-03-08 — — CN disclosed
CN-1161040-A Bicyclic tetrahydro pyrazolopyridines and their use as medicaments PFIZER (US) 1997-10-01 — — CN disclosed
US-5015641-A Dipeptide for vision defects ANDREWS DAVID R (US) 1991-05-14 — — US disclosed
US-4885293-A CARBOXYALKYL DIPEPTIDES SCHERING CORPORATION (US) 1989-12-05 — — US disclosed
EP-0195817-B1 CARBOXYALKYLDIPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORPORATION (US) 1989-10-18 — — EP disclosed
US-4826816-A Antihypertensive compounds SCHERING CORPORATION (US) 1989-05-02 — — US disclosed
CN-1030749-A The method for preparing Fungicidal compounds ICI PLC (GB) 1989-02-01 — — CN disclosed
US-4634698-A TOPICAL HYPOTENSIVES SCHERING CORPORATION (US) 1987-01-06 — — US disclosed
US-4556655-A TREATMENT OF CARDIOVASCULAR DISORDERS AND GLAUCOMA SCHERING CORPORATION (US) 1985-12-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170312262-A9 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF TET1, TET3, EHMT2 TSHR 4426/4885ALDH1A1 1213/4885L3MBTL1 925/4885
US-20260000642-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS BET1, BRD4, PHKB TSHR 951/4885ALDH1A1 4254/4885L3MBTL1 4090/4885
US-20250263370-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS BET1, PHKB, BRD4 TSHR 4030/4885ALDH1A1 4618/4885L3MBTL1 3923/4885
US-10829480-B2 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives OPRD1, OPRK1, OPRL1 TSHR 2129/4885ALDH1A1 473/4885L3MBTL1 2942/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.