Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31257536 | 0.89 | SRC (0.46) | LMNAPTGDR2GAACXCL8NOD1 | |
| SCHEMBL28571863 | 0.80 | ACLY (0.38) | LMNAL3MBTL1KDM4EHTR6 | |
| SCHEMBL10003264 | 0.79 | PTGDR2 (0.39) | LMNAPTGDR2NOD2NOD1L3MBTL1 | |
| SCHEMBL22670414 | 0.75 | LMNA (0.46) | LMNACA1CA2GAACXCL8 | |
| SCHEMBL10003858 | 0.74 | NPSR1 (0.37) | LMNAPTGDR2NOD2NOD1ALDH1A1 | |
| SCHEMBL10003855 | 0.74 | NPSR1 (0.37) | LMNAPTGDR2NOD2NOD1ALDH1A1 | |
| SCHEMBL25172322 | 0.73 | MAPT (0.48) | LMNAGAAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1272442 | 0.72 | ACLY (0.48) | LMNAGAACXCL8NOD2NOD1 | |
| SCHEMBL8545151 | 0.72 | PSEN1 (0.59) | LMNAGAACXCL8NOD2NOD1 | |
| SCHEMBL28571864 | 0.72 | CYP2C19 (0.43) | GAATSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109952295-B | CDK4/6 inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-04-06 | — | — | CN | disclosed |