SCHEMBL28913586

SCHEMBL28913586

N#Cc1ccc(-c2ccc(C#N)c(-n3c4ccc(-c5ccccc5)cc4c4cc(-c5ccccc5)ccc43)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.40
GABRG2 P18507 1/20 0.40
GABRB3 P28472 1/20 0.40
GABRA5 P31644 1/20 0.40
GABRA3 P34903 1/20 0.40
CYP11B2 P19099 2/20 0.39
CYP11B1 P15538 1/20 0.39
ALDH1A3 P47895 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37
MAPK1 P28482 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MAP4K4 O95819 1/20 0.36
MAOA P21397 2/20 0.36
MAOB P27338 2/20 0.36
KAT6A Q92794 1/20 0.36
MCL1 Q07820 1/20 0.35
GSK3B P49841 1/20 0.35
MYC P01106 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28424749 0.94 CYP11B1 (0.39) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL30311704 0.94 CYP11B1 (0.39) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL21116902 0.94 CYP11B1 (0.42) CYP11B2CYP11B1ALDH1A1LMNAHPGD
SCHEMBL21116880 0.94 MAP4K4 (0.39) CYP11B2CYP11B1MAP4K4
SCHEMBL21116882 0.93 RORC (0.40) MAP4K4
SCHEMBL17935058 0.92 ALDH1A1 (0.36) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL20114675 0.92 ABCG2 (0.41) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL21116546 0.90 TSPO (0.40) CYP11B2CYP11B1ALDH1A1LMNAHPGD
SCHEMBL17934864 0.89 KDM4E (0.42) CYP11B2CYP11B1ALDH1A1LMNAHPGD
SCHEMBL23348550 0.89 ALDH1A1 (0.40) CYP11B2CYP11B1ALDH1A1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112638874-A Benzonitrile derivative, light-emitting material, and light-emitting element using the same 国立大学法人九州大学 2021-04-09 CN disclosed