Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 7/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | SCN1A | P35498 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28917337 | 1.00 | LMNA (0.40) | LMNACYP2C9TSHRCHRM2CHRM4 | |
| SCHEMBL21834931 | 0.84 | SCN4A (0.57) | LMNACYP2C9TSHRMAPTSCN4A | |
| SCHEMBL7469831 | 0.83 | KMT2A (0.49) | LMNAMAPTCYP1A2HTTSMN1; SMN2 | |
| SCHEMBL7469838 | 0.83 | KMT2A (0.49) | LMNAMAPTCYP1A2HTTSMN1; SMN2 | |
| SCHEMBL29168977 | 0.79 | HSD17B10 (0.50) | LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL29168975 | 0.79 | HSD17B10 (0.50) | LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL28602971 | 0.78 | MAPT (0.36) | LMNAMAPTCYP2D6SCN9ATHRA | |
| SCHEMBL31460425 | 0.77 | MAPT (0.47) | MAPTCYP1A2HTTSMN1; SMN2KDM4E | |
| SCHEMBL26662208 | 0.77 | MAPT (0.47) | MAPTCYP1A2HTTSMN1; SMN2KDM4E | |
| SCHEMBL16012976 | 0.77 | LMNA (0.55) | LMNAMAPTSCN4ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112920183-A | Compounds as KRAS-G12C inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2021-06-08 | — | — | CN | disclosed |