Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | BMP1 | P13497 | 2/20 | 0.37 |
| ▸ | SLC26A6 | Q9BXS9 | 8/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23114031 | 0.83 | MMP2 (0.37) | MMP2BMP1SLC26A6IDO1ALDH1A1 | |
| SCHEMBL28917534 | 0.82 | DPP4 (0.31) | — | |
| SCHEMBL28917500 | 0.81 | DPP4 (0.32) | — | |
| SCHEMBL8691394 | 0.80 | ALDH1A1 (0.41) | MMP2BMP1SLC26A6IDO1ALDH1A1 | |
| SCHEMBL23983380 | 0.79 | MLYCD (0.39) | MMP2BMP1SLC26A6IDO1ALDH1A1 | |
| SCHEMBL23114080 | 0.76 | MMP2 (0.38) | MMP2BMP1SLC26A6IDO1ALDH1A1 | |
| SCHEMBL463064 | 0.76 | KDM4E (0.42) | MMP2BMP1SLC26A6ALDH1A1CYP1A2 | |
| SCHEMBL17645647 | 0.73 | MMP2 (0.36) | MMP2BMP1SLC26A6ALDH1A1 | |
| SCHEMBL23114193 | 0.70 | MMP2 (0.33) | MMP2BMP1SLC26A6IDO1ALDH1A1 | |
| SCHEMBL8825216 | 0.70 | CYP1A2 (0.43) | MMP2BMP1SLC26A6IDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116589467-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-116589466-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-115485278-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2022-12-16 | — | — | CN | disclosed |