Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.38 |
| ▸ | PRNP | P04156 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31281473 | 0.84 | KDM4E (0.42) | NOTUMALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL23663678 | 0.84 | KDM4E (0.42) | NOTUMALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL28498305 | 0.72 | NOTUM (0.43) | NOTUMALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL21816340 | 0.70 | CAMKK1 (0.53) | NOTUMALDH1A1CAMKK1CAMKK2KDM4E | |
| SCHEMBL28615837 | 0.69 | NOTUM (0.48) | NOTUMALDH1A1SLC22A12PRNPRXFP1 | |
| SCHEMBL3049323 | 0.69 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL28453832 | 0.69 | SLC22A12 (0.44) | ALDH1A1SLC22A12PRNPRXFP1NPSR1 | |
| SCHEMBL28408913 | 0.68 | ALDH1A1 (0.47) | ALDH1A1SLC22A12PRNPRXFP1NPSR1 | |
| SCHEMBL31083856 | 0.67 | NOTUM (0.43) | NOTUMCAMKK1CAMKK2CYP1A2UTS2R | |
| SCHEMBL4569763 | 0.66 | NOTUM (0.41) | NOTUMALDH1A1CAMKK1CAMKK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981268-A | Pyrimidine-4 (3H) -ketone heterocyclic compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-113135910-A | Pyrimidine-4 (3H) -ketone heterocyclic compound, preparation method and pharmaceutical application thereof | 北京诺诚健华医药科技有限公司 | 2021-07-20 | — | — | CN | disclosed |