Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 4/20 | 0.62 |
| ▸ | LTA4H | P09960 | 2/20 | 0.62 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | ANPEP | P15144 | 3/20 | 0.52 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.52 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.52 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5699595 | 1.00 | LAP3 (0.62) | LAP3LTA4HMMP8ANPEPRNPEP | |
| SCHEMBL976802 | 1.00 | LAP3 (0.62) | LAP3LTA4HMMP8ANPEPRNPEP | |
| Hydrochloric Acid SCHEMBL15310163 | 0.98 | LAP3 (0.60) | LAP3LTA4HMMP8ANPEPRNPEP | |
| Hydrochloric Acid SCHEMBL289130 | 0.98 | LAP3 (0.60) | LAP3LTA4HMMP8ANPEPRNPEP | |
| SCHEMBL7417389 | 0.86 | LTA4H (0.53) | LAP3LTA4HSLC7A5 | |
| SCHEMBL2106650 | 0.85 | LTA4H (0.77) | LAP3LTA4HANPEPRNPEPDNPEP | |
| SCHEMBL6339522 | 0.85 | LTA4H (0.77) | LAP3LTA4HANPEPRNPEPDNPEP | |
| SCHEMBL3445511 | 0.85 | LAP3 (0.81) | LAP3LTA4HANPEPRNPEPDNPEP | |
| SCHEMBL7964846 | 0.85 | LTA4H (0.77) | LAP3LTA4HANPEPRNPEPDNPEP | |
| SCHEMBL8174333 | 0.85 | LTA4H (0.77) | LAP3LTA4HANPEPRNPEPDNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427429-B1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBVIE DEUTSCHLAND (DE) | 2017-02-15 | — | — | EP | disclosed |
| US-9527811-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-12-27 | — | — | US | disclosed |
| US-9139557-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-22 | — | — | US | disclosed |
| US-9018206-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-04-28 | — | — | US | disclosed |
| US-20150099786-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-04-09 | — | — | US | disclosed |
| EP-2516393-B1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBVIE DEUTSCHLAND (DE) | 2014-10-29 | — | — | EP | disclosed |
| US-20130245003-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2013-09-19 | — | — | US | disclosed |
| US-20130150367-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT LABORATORIES (US) | 2013-06-13 | — | — | US | disclosed |
| US-8436034-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBOTT GMBH & CO. KG (DE) | 2013-05-07 | — | — | US | disclosed |
| WO-2012166387-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-12-06 | — | — | WO | disclosed |
| US-7799809-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBOTT GMBH & CO. KG (DE) | 2010-09-21 | — | — | US | disclosed |
| US-7728012-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBOTT GMBH & CO. KG (DE) | 2010-06-01 | — | — | US | disclosed |
| EP-2121653-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2009-11-25 | — | — | EP | disclosed |
| US-20080234329-A1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-09-25 | — | — | US | disclosed |
| US-20080234330-A1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-09-25 | — | — | US | disclosed |
| WO-2008080969-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-07-10 | — | — | WO | disclosed |
| EP-1692119-A1 | METHODS OF PREPARING COMPOUNDS USEFUL AS PROTEASE INHIBITORS | PFIZER INC. (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005054214-A1 | METHODS OF PREPARING COMPOUNDS USEFUL AS PROTEASE INHIBITORS | PFIZER INC. (US) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005054214-A1 | METHODS OF PREPARING COMPOUNDS USEFUL AS PROTEASE INHIBITORS | PFIZER INC. (US) | 2005-06-16 | — | — | WO | disclosed |
| US-6103720-A | ENZYME INHIBITORS; ANTIICHEMIC AND -TUMOR AGENTS; STROKES; ALZEIMER'S DISEASE | BASF AKTIENGESELLSCHAFT (DE) | 2000-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150367-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAPN1, CAPN2, CAPNS1 | LAP3 648/4885LTA4H 2808/4885MMP8 2599/4885 |
| US-20080234329-A1 | Carboxamide compounds and their use as calpain inhibitors | CAMK2A, CAPN2, CAPN1 | LAP3 406/4885LTA4H 2478/4885MMP8 2192/4885 |
| US-20080234330-A1 | Carboxamide compounds and their use as calpain inhibitors | CAMK2A, CAPN2, CAPN1 | LAP3 406/4885LTA4H 2478/4885MMP8 2192/4885 |
| US-20150099786-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAPN1, CAPN2, CAPNS1 | LAP3 648/4885LTA4H 2808/4885MMP8 2599/4885 |
| US-20130245003-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAMK2A, CAPN2, CAPN1 | LAP3 406/4885LTA4H 2478/4885MMP8 2192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.