Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7640320 | 0.86 | TSHR (0.57) | PIK3CATSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7641749 | 0.86 | ALDH1A1 (0.48) | TSHRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28923912 | 0.83 | PIK3CA (0.44) | PIK3CATSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23049584 | 0.82 | MEN1 (0.43) | TSHRSMN1; SMN2ALDH1A1MAPTALOX15 | |
| SCHEMBL5808567 | 0.81 | MAPT (0.52) | TSHRSMN1; SMN2ALDH1A1MAPTALOX15 | |
| SCHEMBL30965434 | 0.79 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL20681282 | 0.79 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL5792784 | 0.79 | MAPT (0.49) | PIK3CASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL1699588 | 0.78 | PIK3CA (0.44) | PIK3CATSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1699591 | 0.78 | PIK3CA (0.44) | PIK3CATSHRSMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109761986-B | Tricyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-10-08 | — | — | CN | disclosed |