Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28923911 | 0.83 | PIK3CA (0.48) | PIK3CATSHRSMN1; SMN2KCNJ6KCNJ5 | |
| SCHEMBL28638605 | 0.83 | PIK3CA (0.50) | PIK3CATSHRKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL28547028 | 0.75 | MEN1 (0.49) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL20681282 | 0.75 | TSHR (0.57) | TSHRSMN1; SMN2MMEACEALDH1A1 | |
| SCHEMBL30965434 | 0.75 | TSHR (0.57) | TSHRSMN1; SMN2MMEACEALDH1A1 | |
| SCHEMBL1699591 | 0.74 | PIK3CA (0.44) | PIK3CATSHRSMN1; SMN2KCNJ6KCNJ5 | |
| SCHEMBL1699588 | 0.74 | PIK3CA (0.44) | PIK3CATSHRSMN1; SMN2KCNJ6KCNJ5 | |
| SCHEMBL869116 | 0.73 | CA2 (0.65) | PIK3CATSHRRPA1CA2ALDH1A1 | |
| SCHEMBL15262338 | 0.73 | CYP2C9 (0.40) | PIK3CATSHRSMN1; SMN2MMEACE | |
| SCHEMBL901787 | 0.72 | CYP4F2 (0.56) | PIK3CATSHRSMN1; SMN2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109761986-B | Tricyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-10-08 | — | — | CN | disclosed |