Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | PRKDC | P78527 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28640313 | 0.84 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL28631330 | 0.80 | BRAF (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL28635804 | 0.80 | BRAF (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL28924973 | 0.76 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL561236 | 0.75 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL28961950 | 0.73 | BRAF (0.61) | PIK3CABRAFMETAP2RAF1CREBBP | |
| SCHEMBL2195217 | 0.72 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL17739228 | 0.70 | CYP11B1 (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL22886577 | 0.70 | BRAF (0.57) | PIK3CABRAFMETAP2CREBBPBRD4 | |
| SCHEMBL28640314 | 0.69 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106659765-B | Use of dianhydrogalactitol and analogs or derivatives thereof for treating non-small cell lung cancer and ovarian cancer | 德玛医药 | 2021-08-13 | — | — | CN | disclosed |