Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.52 |
| ▸ | METAP2 | P50579 | 3/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28924973 | 0.82 | PIK3CA (0.56) | PIK3CAMETAP2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL3433766 | 0.81 | METAP2 (0.51) | PIK3CAMETAP2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL3435046 | 0.78 | BRD4 (0.56) | PIK3CAMETAP2BRAFRAF1BRD4 | |
| SCHEMBL28640313 | 0.75 | PIK3CA (0.59) | PIK3CAMETAP2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL3435505 | 0.74 | METAP2 (0.48) | PIK3CAMETAP2BRAFLRRK2BRD4 | |
| SCHEMBL561550 | 0.70 | PIK3CA (0.75) | PIK3CAMETAP2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2193765 | 0.69 | PIK3CA (0.82) | PIK3CAMETAP2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL28924972 | 0.69 | PIK3CA (0.60) | PIK3CAMETAP2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2194222 | 0.68 | PIK3CA (1.00) | PIK3CAMETAP2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL17739226 | 0.67 | METAP2 (0.62) | METAP2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106659765-B | Use of dianhydrogalactitol and analogs or derivatives thereof for treating non-small cell lung cancer and ovarian cancer | 德玛医药 | 2021-08-13 | — | — | CN | disclosed |