Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026935 | 0.89 | NPC1 (0.51) | MAPTL3MBTL1NPC1RXRATHRA | |
| SCHEMBL21647816 | 0.85 | LRRK2 (0.47) | LMNAMAPTL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL29413361 | 0.79 | THRB (0.56) | KMT2AMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL3841280 | 0.79 | THRB (0.56) | KMT2AMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL27849251 | 0.78 | NPC1 (0.53) | KMT2ALMNAMAPTL3MBTL1NPC1 | |
| SCHEMBL7104109 | 0.77 | THRB (0.51) | KMT2ALMNAMAPTL3MBTL1NPC1 | |
| SCHEMBL10717803 | 0.77 | L3MBTL1 (0.50) | RAB9ALMNAMAPTL3MBTL1NPC1 | |
| SCHEMBL819105 | 0.76 | THRB (0.56) | LMNAMAPTL3MBTL1ALDH1A1THRA | |
| SCHEMBL30197447 | 0.76 | THRB (0.56) | LMNAMAPTL3MBTL1ALDH1A1THRA | |
| SCHEMBL28820774 | 0.76 | ABCB1 (0.54) | MAPTAKR1C3SLC1A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153636-B | Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors | 朱比连特埃皮科尔有限责任公司 | 2021-10-22 | — | — | CN | disclosed |