Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28929418 | 0.87 | NPC1 (0.59) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL28928852 | 0.87 | GAA (0.42) | NPC1RAB9AKDM4EGAALMNA | |
| SCHEMBL28928821 | 0.85 | GAA (0.47) | NPC1RAB9AKDM4EGAALMNA | |
| SCHEMBL28928836 | 0.82 | KDM4E (0.43) | KDM4EGAALMNAPOLBMEN1 | |
| SCHEMBL28928858 | 0.82 | NPC1 (0.44) | NPC1RAB9AKDM4EGAALMNA | |
| SCHEMBL28962239 | 0.80 | DAO (0.46) | SMN1; SMN2KMT2A | |
| SCHEMBL28928859 | 0.79 | POLB (0.52) | RAB9AKDM4EGAALMNAPOLB | |
| SCHEMBL28928823 | 0.78 | LMNA (0.65) | NPC1RAB9AKDM4ELMNAPOLB | |
| SCHEMBL28928830 | 0.78 | MEN1 (0.64) | NPC1RAB9AKDM4EGAALMNA | |
| SCHEMBL27855054 | 0.78 | HDAC3 (0.48) | NPC1RAB9AKDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115583942-A | 2-substituted 5-phenyl-oxazole derivative, preparation method thereof and application thereof as MNK (MNK) inhibitor | 中国海洋大学 | 2023-01-10 | — | — | CN | disclosed |