Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.59 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 6/20 | 0.39 |
| ▸ | NOS1 | P29475 | 5/20 | 0.39 |
| ▸ | NOS3 | P29474 | 4/20 | 0.39 |
| ▸ | ARG2 | P78540 | 4/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28689762 | 0.91 | GSR (0.67) | GSRDDAH1NOS2NOS1NOS3 | |
| SCHEMBL5533751 | 0.84 | DDAH1 (0.53) | GSRDDAH1NOS2NOS1NOS3 | |
| Lysine SCHEMBL28676597 | 0.84 | GSR (0.61) | GSRDDAH1NOS2NOS1NOS3 | |
| SCHEMBL14508685 | 0.82 | DDAH1 (0.54) | GSRDDAH1NOS2NOS1NOS3 | |
| D-Glutamate SCHEMBL28157975 | 0.82 | GRM8 (0.56) | GSRDDAH1NOS2NOS1NOS3 | |
| Lysine SCHEMBL28278541 | 0.81 | GSR (0.83) | GSRDDAH1NOS2NOS1NOS3 | |
| Alanine SCHEMBL28494565 | 0.79 | MEN1 (0.44) | DDAH1NOS2NOS1NOS3TSHR | |
| SCHEMBL30508517 | 0.79 | NOS3 (0.57) | GSRDDAH1NOS2NOS1NOS3 | |
| Lysine SCHEMBL27895772 | 0.79 | GSR (0.87) | GSRNOS2NOS1NOS3ARG2 | |
| Lysine SCHEMBL27881240 | 0.79 | GSR (0.87) | GSRNOS2NOS1NOS3ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109438568-B | Preparation and application of monodisperse polyethylene glycol monomethyl ether modified interleukin IL-12 prodrug | 湖南华腾制药有限公司 | 2022-01-11 | — | — | CN | disclosed |