SCHEMBL28932011

SCHEMBL28932011

CC(C)(C)C1C(NC(=O)OCc2ccccc2)C(F)CN1C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.46
GAA P10253 1/20 0.46
DPP4 P27487 4/20 0.45
DPP7 Q9UHL4 4/20 0.45
CPB1 P15086 2/20 0.43
CTSL P07711 1/20 0.43
CTSB P07858 1/20 0.43
CTSK P43235 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
TSHR P16473 1/20 0.42
NAAA Q02083 3/20 0.42
KCNH2 Q12809 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2535000 0.88 ALDH1A1 (0.47) ALDH1A1GAACPB1CTSLCTSB
SCHEMBL2537464 0.88 ALDH1A1 (0.47) ALDH1A1GAACPB1CTSLCTSB
SCHEMBL3741628 0.88 ALDH1A1 (0.47) ALDH1A1GAACPB1CTSLCTSB
SCHEMBL23275255 0.88 ALDH1A1 (0.47) ALDH1A1GAACPB1CTSLCTSB
SCHEMBL14801909 0.86 ALDH1A1 (0.44) ALDH1A1GAADPP4DPP7CPB1
SCHEMBL14801236 0.86 ALDH1A1 (0.44) ALDH1A1GAADPP4DPP7CPB1
SCHEMBL20479381 0.83 CPB1 (0.45) ALDH1A1GAACPB1CTSLCTSB
SCHEMBL20974421 0.82 ALDH1A1 (0.42) ALDH1A1GAACPB1CTSLCTSB
SCHEMBL2540745 0.82 ALDH1A1 (0.42) ALDH1A1GAACPB1CTSLCTSB
SCHEMBL18342363 0.82 ALDH1A1 (0.42) ALDH1A1GAACPB1CTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109071560-B Thienopyridine carboxamides as ubiquitin-specific protease inhibitors 瓦洛健康公司 2022-01-14 CN disclosed