SCHEMBL28945489

SCHEMBL28945489

FC(F)(F)c1cc(I)ccc1-c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 8/20 0.43
S1PR3 Q99500 4/20 0.43
GLA P06280 1/20 0.39
POLB P06746 1/20 0.39
GAA P10253 1/20 0.39
TSHR P16473 1/20 0.39
AKR1C3 P42330 5/20 0.38
AKR1C2 P52895 5/20 0.38
KIF11 P52732 1/20 0.38
RORC P51449 1/20 0.37
AR P10275 2/20 0.37
SCN9A Q15858 1/20 0.36
AKR1C4 P17516 1/20 0.36
AKR1C1 Q04828 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3845967 0.88 GLA (0.42) S1PR1S1PR3GLAPOLBGAA
SCHEMBL3534403 0.83 GLA (0.54) GLAPOLBGAATSHRAKR1C3
SCHEMBL25011732 0.82 GLA (0.45) GLAPOLBGAATSHRAKR1C3
SCHEMBL27638533 0.80 S1PR1 (0.52) S1PR1S1PR3GLAPOLBGAA
SCHEMBL4781603 0.78 KIF11 (0.54) S1PR1S1PR3TSHRKIF11SCN9A
SCHEMBL17629903 0.78 KIF11 (0.51) KIF11AR
SCHEMBL2942635 0.77 S1PR1 (0.47) S1PR1S1PR3GLAPOLBGAA
SCHEMBL4664391 0.77 S1PR1 (0.43) S1PR1S1PR3GLAPOLBGAA
SCHEMBL1802128 0.77 ALOX5 (0.59) S1PR1S1PR3KIF11AR
SCHEMBL4637120 0.77 AKR1C3 (0.51) S1PR1S1PR3AKR1C3AKR1C2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113943287-B Polycyclic aromatic compound and application thereof in electroluminescent device 清华大学 2023-02-03 CN disclosed