Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 12/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 10/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 10/20 | 0.56 |
| ▸ | PIM1 | P11309 | 3/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.56 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 10/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.46 |
| ▸ | CLK2 | P49760 | 8/20 | 0.46 |
| ▸ | CLK3 | P49761 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DYRK4 | Q9NR20 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30145008 | 1.00 | KDM4E (0.58) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL30145012 | 0.88 | MAPT (0.56) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL23987070 | 0.88 | MAPT (0.56) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL25590187 | 0.84 | CLK1 (0.52) | DYRK1ADYRK1BDYRK3DYRK2PIM1 | |
| SCHEMBL30145002 | 0.81 | CLK1 (0.60) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL23510493 | 0.81 | CLK1 (0.60) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL28842886 | 0.81 | CLK1 (0.60) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL24904263 | 0.78 | KDM4E (0.64) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL30363461 | 0.78 | KDM4E (0.64) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL23510596 | 0.77 | KDM4E (0.59) | KDM4EDYRK1ADYRK1BDYRK3DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515953-A | Novel imidazolidinone derivatives as inhibitors of protein kinases, in particular DYRK1A, CLK1 and/or CLK4 | 珀哈制药公司 | 2022-12-23 | — | — | CN | disclosed |