Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 11/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 9/20 | 0.54 |
| ▸ | DYRK2 | Q92630 | 9/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.54 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 8/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.48 |
| ▸ | CLK2 | P49760 | 6/20 | 0.48 |
| ▸ | CLK3 | P49761 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30145012 | 1.00 | MAPT (0.56) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL30145008 | 0.88 | KDM4E (0.58) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL28945547 | 0.88 | KDM4E (0.58) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL25590187 | 0.87 | CLK1 (0.52) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL30144962 | 0.80 | CLK1 (0.60) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL23970084 | 0.80 | CLK1 (0.60) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL26092928 | 0.77 | MAPT (0.62) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL30363453 | 0.77 | MAPT (0.62) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL26096202 | 0.76 | MAPT (0.58) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL30275506 | 0.76 | CLK1 (0.51) | MAPTGAADYRK1ADYRK1BDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-06-01 | — | — | US | disclosed |
| CN-115515953-A | Novel imidazolidinone derivatives as inhibitors of protein kinases, in particular DYRK1A, CLK1 and/or CLK4 | 珀哈制药公司 | 2022-12-23 | — | — | CN | disclosed |
| WO-2021219828-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | CLK1, CLK2, CLK3 | MAPT 326/4885GAA 4095/4885DYRK1A 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.