Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 11/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 9/20 | 0.54 |
| ▸ | DYRK2 | Q92630 | 9/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.54 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 8/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.48 |
| ▸ | CLK2 | P49760 | 6/20 | 0.48 |
| ▸ | CLK3 | P49761 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23987070 | 1.00 | MAPT (0.56) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL30145008 | 0.88 | KDM4E (0.58) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL28945547 | 0.88 | KDM4E (0.58) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL25590187 | 0.87 | CLK1 (0.52) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL30144962 | 0.80 | CLK1 (0.60) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL23970084 | 0.80 | CLK1 (0.60) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL26092928 | 0.77 | MAPT (0.62) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL30363453 | 0.77 | MAPT (0.62) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL26096202 | 0.76 | MAPT (0.58) | MAPTGAADYRK1ADYRK1BDYRK3 | |
| SCHEMBL30275506 | 0.76 | CLK1 (0.51) | MAPTGAADYRK1ADYRK1BDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143185-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-03-08 | — | — | EP | disclosed |
| CN-115515953-A | Novel imidazolidinone derivatives as inhibitors of protein kinases, in particular DYRK1A, CLK1 and/or CLK4 | 珀哈制药公司 | 2022-12-23 | — | — | CN | disclosed |