Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.53 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.53 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29661290 | 0.78 | TXNRD1 (0.53) | TXNRD1TXNRD3TXNRD2TDP1ALDH1A1 | |
| SCHEMBL5723712 | 0.78 | TXNRD1 (0.53) | TXNRD1TXNRD3TXNRD2ATMTDP1 | |
| SCHEMBL24327364 | 0.78 | TXNRD1 (0.53) | TXNRD1TXNRD3TXNRD2TDP1ALDH1A1 | |
| SCHEMBL608552 | 0.78 | TXNRD1 (0.53) | TXNRD1TXNRD3TXNRD2TDP1ALDH1A1 | |
| SCHEMBL4491664 | 0.75 | TXNRD1 (0.50) | TXNRD1TXNRD3TXNRD2TDP1ALDH1A1 | |
| SCHEMBL4495775 | 0.75 | TXNRD1 (0.54) | TXNRD1TXNRD3TXNRD2ALDH1A1VCAM1 | |
| SCHEMBL28729994 | 0.75 | ATM (0.39) | TXNRD1TXNRD3TXNRD2ATMTDP1 | |
| SCHEMBL3540216 | 0.74 | TXNRD1 (0.49) | TXNRD1TXNRD3TXNRD2TDP1ALDH1A1 | |
| SCHEMBL6257481 | 0.70 | TXNRD1 (0.62) | TXNRD1TXNRD3TXNRD2TDP1ALDH1A1 | |
| SCHEMBL30379968 | 0.70 | TXNRD1 (0.62) | TXNRD1TXNRD3TXNRD2TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |