SCHEMBL28958183

SCHEMBL28958183

N#Cc1ccc(C2CC2(F)F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 1/20 0.39
CYP2A6 P11509 2/20 0.38
ALDH1A1 P00352 1/20 0.38
CA12 O43570 1/20 0.38
CA2 P00918 1/20 0.38
CA3 P07451 1/20 0.38
CA6 P23280 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
PGR P06401 1/20 0.37
KDM4E B2RXH2 1/20 0.36
TP53 P04637 1/20 0.36
TSHR P16473 1/20 0.36
KIF11 P52732 1/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
CYP19A1 P11511 2/20 0.35
KDM1A O60341 2/20 0.35
HTR7 P34969 1/20 0.35
LOXL2 Q9Y4K0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28590433 0.82 HTR7 (0.38) CYP11B2CYP2A6ALDH1A1CA12CA2
SCHEMBL29729003 0.79 DRD2 (0.34) KDM1A
SCHEMBL31510742 0.78 KDM1A (0.39) CYP11B2MAOAMAOBCYP19A1KDM1A
SCHEMBL30125283 0.77 DRD2 (0.47) TSHRMAOAMAOBKDM1AENPP2
SCHEMBL28958186 0.77 DRD2 (0.47) TSHRMAOAMAOBKDM1AENPP2
SCHEMBL10555053 0.74 KDM1A (0.34) CYP11B2CYP2A6ALDH1A1MAOAMAOB
SCHEMBL22926165 0.72 MEN1 (0.33)
SCHEMBL23554855 0.71 KDM1A (0.35) MAOAMAOBKDM1A
SCHEMBL23964612 0.71 MAOB (0.48) ALDH1A1MAOAMAOBKDM1A
SCHEMBL29989472 0.71 KDM1A (0.48) CYP2A6TSHRMAOBKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115584516-A Method for electrochemically inducing defluorination carboxylation reaction of difluorocyclopropane 南京林业大学 2023-01-10 CN claimed
CN-115584516-A Method for electrochemically inducing defluorination carboxylation reaction of difluorocyclopropane 南京林业大学 2023-01-10 CN disclosed