Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.32 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8838164 | 0.80 | HCAR2 (0.39) | RAB9A | |
| SCHEMBL221749 | 0.80 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10ALOX15CHRM5 | |
| SCHEMBL74779 | 0.80 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10ALOX15CHRM5 | |
| SCHEMBL271027 | 0.80 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10ALOX15CHRM5 | |
| SCHEMBL19082588 | 0.79 | TSHR (0.42) | ALDH1A1TSHR | |
| SCHEMBL433700 | 0.77 | ALDH1A1 (0.39) | ALDH1A1LMNAHSD17B10ALOX15CHRM5 | |
| SCHEMBL11039206 | 0.75 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10ALOX15CHRM5 | |
| SCHEMBL11039208 | 0.75 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10ALOX15CHRM5 | |
| SCHEMBL469873 | 0.73 | — | — | |
| SCHEMBL280688 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791123-A1 | PROCESS FOR PREPARATION OF 3-((2S,5S)-4-METHYLENE-5-(3-OXOPROPYL)TETRAHYDROFURAN-2-YL) PROPANOL DERIVATIVES AND INTERMEDIATES USEFUL THEREOF | Alphora Research Inc. (CA) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013086634-A1 | PROCESS FOR PREPARATION OF 3-((2S,5S)-4-METHYLENE-5-(3-OXOPROPYL)TETRAHYDROFURAN-2-YL) PROPANOL DERIVATIVES AND INTERMEDIATES USEFUL THEREOF | ALPHORA RESEARCH INC. (CA) | 2013-06-20 | — | — | WO | disclosed |
| US-7662846-B2 | Selective spirocyclic glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-02-16 | — | — | US | disclosed |
| EP-1617806-B1 | SELECTIVE SPIROCYCLIC GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2009-11-04 | — | — | EP | disclosed |
| EP-1617806-A4 | SELECTIVE SPIROCYCLIC GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20060217563-A1 | Selective spirocyclic glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. | 2006-09-28 | — | — | US | disclosed |
| EP-1617806-A2 | SELECTIVE SPIROCYCLIC GLUCOCORTICOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004093805-A2 | SELECTIVE SPIROCYCLIC GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217563-A1 | Selective spirocyclic glucocorticoid receptor modulators | NR3C2, NR3C1, MC2R | ALDH1A1 1580/4885LMNA 4098/4885HSD17B10 510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.