Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290196 | 0.87 | SMN1; SMN2 (0.40) | NPC1RAB9AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL289628 | 0.80 | SMN1; SMN2 (0.63) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL288852 | 0.79 | KDM4E (0.59) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL289614 | 0.77 | KDM4E (0.64) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL289540 | 0.74 | KDM4E (0.54) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL290020 | 0.73 | KDM4E (0.56) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL290390 | 0.73 | CDC7 (0.61) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL290184 | 0.72 | CDC7 (0.56) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL289663 | 0.71 | JAK2 (0.47) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL290095 | 0.71 | KDM4E (0.53) | NPC1RAB9AKMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |