SCHEMBL28964474

SCHEMBL28964474

CS(=O)(=O)c1cccc2onnc12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.34
ALDH1A1 P00352 2/20 0.34
KDM4E B2RXH2 1/20 0.34
KMT2A Q03164 4/20 0.33
HSD11B1 P28845 1/20 0.33
LMNA P02545 3/20 0.31
TP53 P04637 1/20 0.31
HTT P42858 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
POLB P06746 1/20 0.31
MEN1 O00255 3/20 0.30
LOX P28300 1/20 0.30
NPC1 O15118 1/20 0.30
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA3 P07451 1/20 0.30
CA4 P22748 1/20 0.30
CA6 P23280 1/20 0.30
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL329379 0.84
SCHEMBL6390852 0.82 TTR (0.37) ALDH1A1KMT2APOLBMEN1
SCHEMBL4786290 0.82 ALDH1A1 (0.33) ALDH1A1
SCHEMBL4202430 0.82 CA2 (0.46) LMNAHTTNPC1CA12CA1
SCHEMBL15345322 0.81 POLB (0.49) RAB9AALDH1A1LMNAHTTSMN1; SMN2
SCHEMBL20837055 0.71 EPHB4 (0.42) RAB9AALDH1A1KDM4EKMT2AMEN1
SCHEMBL329373 0.71
SCHEMBL10415893 0.71 ELANE (0.35) RAB9AALDH1A1KDM4ESMN1; SMN2NPC1
SCHEMBL28648952 0.70 GABRA1 (0.39) ALDH1A1KDM4EKMT2AMEN1
SCHEMBL329559 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118510515-A Pyridazindione-based double-heterocycle covalent linker, method and application thereof 信特生物有限责任公司 2024-08-16 CN disclosed
CN-117157107-A Multifunctional antibody 西纳福克斯股份有限公司 2023-12-01 CN disclosed
CN-116768816-A Arylation coupling agent, fluorescent dye conjugate and related application 北京大学 2023-09-19 CN disclosed
CN-115768483-A Conjugates of antibodies and immune cell adaptors 西纳福克斯股份有限公司 2023-03-07 CN disclosed