Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tilorone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.94 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.94 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tilorone SCHEMBL29500271 | 0.97 | MAPT (1.00) | MAPTKMT2ACHRNA7POLBHTT | |
| Tilorone SCHEMBL352401 | 0.97 | MAPT (1.00) | MAPTKMT2ACHRNA7POLBHTT | |
| Tilorone SCHEMBL30520073 | 0.97 | MAPT (1.00) | MAPTKMT2ACHRNA7POLBHTT | |
| Tilorone SCHEMBL30882954 | 0.95 | MAPT (0.97) | MAPTKMT2ACHRNA7POLBHTT | |
| Tilorone SCHEMBL30002597 | 0.95 | MAPT (0.97) | MAPTKMT2ACHRNA7POLBHTT | |
| Tilorone SCHEMBL3701437 | 0.95 | MAPT (0.97) | MAPTKMT2ACHRNA7POLBHTT | |
| Tilorone SCHEMBL146373 | 0.95 | MAPT (0.97) | MAPTKMT2ACHRNA7POLBHTT | |
| Tilorone SCHEMBL30882955 | 0.95 | MAPT (0.97) | MAPTKMT2ACHRNA7POLBHTT | |
| Tilorone SCHEMBL11257327 | 0.95 | MAPT (0.97) | MAPTKMT2ACHRNA7POLBHTT | |
| SCHEMBL146374 | 0.94 | MAPT (0.94) | MAPTKMT2ACHRNA7POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115590836-B | Lipid nanoparticle for improving immune response induction capability of mRNA vaccine and application thereof | 浙江大学 | 2024-06-21 | — | — | CN | disclosed |
| CN-115590836-A | Lipid nanoparticle for improving mRNA vaccine induced immune response capability and application thereof | 浙江大学（CN） | 2023-01-13 | — | — | CN | disclosed |