SCHEMBL289670

SCHEMBL289670

Nc1c(Cl)cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc1Br

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
ALDH1A1 P00352 2/20 0.31
KDM4E B2RXH2 1/20 0.31
POLB P06746 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CYP3A4 P08684 1/20 0.30
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL289233 0.91 CA1 (0.43) CA1CA2CA9ALDH1A1KDM4E
SCHEMBL18355927 0.88 CA1 (0.41) CA1CA2CA9ALDH1A1KDM4E
SCHEMBL289962 0.87 ALDH1A1 (0.41) CA1CA2CA9ALDH1A1KDM4E
SCHEMBL298983 0.87 GAA (0.41) CA1CA2CA9GAAMAPT
SCHEMBL16207359 0.82 CA1 (0.37) CA1CA2CA9
SCHEMBL13968273 0.81 CA1 (0.39) CA1CA2CA9
SCHEMBL999095 0.81 ADRB2 (0.36) GAAMAPT
SCHEMBL7713740 0.80 CA1 (0.46) CA1CA2CA9ALDH1A1KDM4E
SCHEMBL29778899 0.80 CA1 (0.46) CA1CA2CA9ALDH1A1KDM4E
SCHEMBL13515983 0.79 ADRB2 (0.38) ALDH1A1KDM4EPOLBSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044028-B1 CYANOISOQUINOLINE COMPOUNDS THAT STABILIZE HYPOXIA INDUCIBLE FACTOR (HIF) FIBROGEN INC (US) 2012-05-16 EP claimed
EP-1115693-B9 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO CO (US) 2007-12-19 EP claimed
EP-1115693-B1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO CO (US) 2007-05-02 EP claimed
CN-106242998-B Use of 4-cyano-3-benzoylamino-N-phenyl-benzamides in pesticides 先正达参股股份有限公司 2021-11-05 CN disclosed
EP-3366675-A1 INSECTICIDAL 2-METHOXYBENZAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2018-08-29 EP disclosed
EP-3339286-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-06-27 EP disclosed
EP-2763966-B1 INSECTICIDAL 2-METHOXYBENZAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2018-04-04 EP disclosed
EP-2427426-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-02-07 EP disclosed
US-9023873-B2 Insecticidal 2-methoxybenzamide derivatives SYNGENTA PARTICIPATIONS AG (CH) 2015-05-05 US disclosed
US-9023873-B2 Insecticidal 2-methoxybenzamide derivatives SYNGENTA PARTICIPATIONS AG (CH) 2015-05-05 US disclosed
US-9023873-B2 Insecticidal 2-methoxybenzamide derivatives SYNGENTA PARTICIPATIONS AG (CH) 2015-05-05 US disclosed
EP-1313735-A1 LIQUID CRYSTALLINE 3,4:9,10-PERYLENETETRACARBOXYLIC ACID DIIMIDES BASF AKTIENGESELLSCHAFT (DE) 2003-05-28 EP disclosed
WO-2002014318-A1 LIQUID CRYSTALLINE 3,4:9,10-PERYLENETETRACARBOXYLIC ACID DIIMIDES BASF AKTIENGESELLSCHAFT (DE) 2002-02-21 WO disclosed
EP-0692517-B1 Process for the preparation of crosslinked polymer particles containing fluorescent dyes BASF AG (DE) 2000-10-18 EP disclosed
EP-0698649-A1 Use of thermoplastically processible long time stable electroluminescent materials BASF AKTIENGESELLSCHAFT (DE) 1996-02-28 EP disclosed
EP-0692517-A1 Crosslinked polymer particules containing fluorescent dyes BASF AKTIENGESELLSCHAFT (DE) 1996-01-17 EP disclosed
EP-0422474-B1 Fluorescent pigments BASF AG (DE) 1995-11-29 EP disclosed
EP-0422535-B1 Polymerisable perylene-3,4,9,10-tetracarboxylic diimides and polymeric products thereof BASF AG (DE) 1994-03-02 EP disclosed
EP-0432445-B1 FLUORESCENT PRINTING INK BASF Lacke + Farben AG (DE) 1993-06-02 EP disclosed
EP-0422535-A1 Polymerisable perylene-3,4,9,10-tetracarboxylic diimides and polymeric products thereof BASF Aktiengesellschaft (DE) 1991-04-17 EP disclosed