Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19066927 | 0.90 | CA2 (0.55) | CA2ATMMAPTCA1MAPK1 | |
| SCHEMBL1898130 | 0.90 | CA2 (0.55) | CA2ATMMAPTCA1MAPK1 | |
| SCHEMBL25239652 | 0.90 | CA2 (0.55) | CA2ATMMAPTCA1MAPK1 | |
| SCHEMBL10825132 | 0.90 | CA2 (0.55) | CA2ATMMAPTCA1MAPK1 | |
| SCHEMBL1673909 | 0.90 | CA2 (0.55) | CA2ATMMAPTCA1MAPK1 | |
| SCHEMBL9347111 | 0.88 | CA2 (0.53) | CA2ATMMAPTCA1MAPK1 | |
| SCHEMBL9007870 | 0.88 | CA2 (0.53) | CA2ATMMAPTCA1MAPK1 | |
| SCHEMBL9770021 | 0.88 | CA2 (0.52) | CA2ATMMAPTCA1GRIK1 | |
| SCHEMBL9770089 | 0.88 | CA2 (0.52) | CA2ATMMAPTCA1GRIK1 | |
| SCHEMBL9770034 | 0.88 | CA2 (0.52) | CA2ATMMAPTCA1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115772305-A | Preparation method of CPVC cold and hot water pipe | 金川集团股份有限公司 | 2023-03-10 | — | — | CN | disclosed |