SCHEMBL28969167

SCHEMBL28969167

C[CH][C@@H](C)c1ccc(O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 10/20 0.56
ESR2 Q92731 8/20 0.56
PDCD1 Q15116 1/20 0.56
CD274 Q9NZQ7 1/20 0.56
LMNA P02545 3/20 0.44
CYP3A4 P08684 3/20 0.44
MAPT P10636 3/20 0.44
ALOX15 P16050 3/20 0.44
CYP2C9 P11712 3/20 0.44
CYP1A2 P05177 2/20 0.44
ADORA3 P0DMS8 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2C19 P33261 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
PGR P06401 1/20 0.44
CHRM2 P08172 1/20 0.44
AR P10275 1/20 0.44
CHRM1 P11229 1/20 0.44
DRD1 P21728 1/20 0.44
TBXA2R P21731 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28969210 1.00 ESR1 (0.56) ESR1ESR2PDCD1CD274LMNA
SCHEMBL7934565 0.78 ESR1 (0.54) ESR1ESR2PDCD1CD274LMNA
SCHEMBL351626 0.78 ESR1 (0.54) ESR1ESR2PDCD1CD274LMNA
SCHEMBL7009501 0.78 ESR1 (0.54) ESR1ESR2PDCD1CD274LMNA
SCHEMBL4759107 0.76 ESR1 (0.52) ESR1ESR2PDCD1CD274LMNA
SCHEMBL27643370 0.75 ADRB2 (0.52) LMNATDP1SLC6A2SLC6A3HIF1A
SCHEMBL27641817 0.75 ESR1 (0.50) ESR1ESR2PDCD1CD274LMNA
SCHEMBL27330191 0.75 IDO1 (0.39) MEN1KMT2ATRPA1
SCHEMBL185170 0.74 TRPA1 (0.50) LMNACYP2D6HIF1AKDM4EALDH1A1
SCHEMBL21331657 0.74 TRPA1 (0.50) LMNACYP2D6HIF1AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115667277-A GPR40 agonists 卡尔优普公司 2023-01-31 CN disclosed