Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNF114 | Q9Y508 | 1/20 | 0.70 |
| ▸ | YAP1 | P46937 | 2/20 | 0.64 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28969657 | 0.89 | RNF114 (0.64) | RNF114YAP1TEAD4L3MBTL1ACHE | |
| SCHEMBL25122626 | 0.82 | RNF114 (0.83) | RNF114YAP1TEAD4L3MBTL1KDM4E | |
| SCHEMBL30688878 | 0.81 | RNF114 (0.88) | RNF114YAP1TEAD4ACHECACNA1H | |
| SCHEMBL29129845 | 0.81 | RNF114 (0.69) | RNF114YAP1TEAD4L3MBTL1HDAC4 | |
| SCHEMBL23518678 | 0.80 | RNF114 (0.91) | RNF114YAP1TEAD4L3MBTL1ACHE | |
| SCHEMBL23518782 | 0.80 | RNF114 (0.78) | RNF114YAP1TEAD4L3MBTL1ACHE | |
| SCHEMBL27465865 | 0.79 | RNF114 (0.88) | RNF114YAP1TEAD4L3MBTL1ACHE | |
| SCHEMBL21392773 | 0.73 | YAP1 (1.00) | RNF114YAP1TEAD4MAOAMAOB | |
| SCHEMBL4284638 | 0.72 | PPARA (0.58) | HDAC4HDAC8 | |
| SCHEMBL8355954 | 0.72 | PPARA (0.61) | L3MBTL1HDAC4HDAC8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115819423-B | PROTAC compound of adefovir or intermediate thereof, preparation method thereof and application of PROTAC compound in EV71 resistance | 武汉大学 | 2024-11-22 | — | — | CN | disclosed |
| CN-115819423-A | ProTAC compound of Reidesciclovir or intermediate thereof, preparation method thereof and application of anti-EV 71 | 武汉大学 | 2023-03-21 | — | — | CN | disclosed |