Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNF114 | Q9Y508 | 1/20 | 0.88 |
| ▸ | YAP1 | P46937 | 4/20 | 0.79 |
| ▸ | TEAD4 | Q15561 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23518678 | 0.89 | RNF114 (0.91) | RNF114YAP1TEAD4NPSR1MEN1 | |
| SCHEMBL30688878 | 0.88 | RNF114 (0.88) | RNF114YAP1TEAD4MAPTKMT2A | |
| SCHEMBL25122626 | 0.88 | RNF114 (0.83) | RNF114YAP1TEAD4L3MBTL1 | |
| SCHEMBL16938347 | 0.86 | MEN1 (0.68) | RNF114YAP1TEAD4MAPTNPSR1 | |
| SCHEMBL23518782 | 0.85 | RNF114 (0.78) | RNF114YAP1TEAD4ACHEL3MBTL1 | |
| SCHEMBL28969681 | 0.79 | RNF114 (0.70) | RNF114YAP1TEAD4ACHEMAOA | |
| SCHEMBL21392773 | 0.79 | YAP1 (1.00) | RNF114YAP1TEAD4MAPTKMT2A | |
| SCHEMBL29129845 | 0.78 | RNF114 (0.69) | RNF114YAP1TEAD4ACHEL3MBTL1 | |
| SCHEMBL28969657 | 0.77 | RNF114 (0.64) | RNF114YAP1TEAD4NPSR1ACHE | |
| SCHEMBL21392919 | 0.76 | YAP1 (0.83) | RNF114YAP1TEAD4MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024127022-A1 | HETEROCYCLIC COMPOUNDS TARGETING THE NUDT5 PROTEIN | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2024-06-20 | — | — | WO | disclosed |