Benzoic Acid

Benzoic Acid

SCHEMBL2897121

C=CC(=O)OCC.N#Cc1ccccc1-c1ccccc1.O=C(O)c1ccccc1

nearest known ligand 0.43

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Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D

The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GRIA2 P42262 1/20 0.43
GRIA4 P48058 1/20 0.43
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 4/20 0.41
L3MBTL1 Q9Y468 3/20 0.41
TDP1 Q9NUW8 3/20 0.41
LMNA P02545 1/20 0.41
HPGD P15428 1/20 0.41
GAA P10253 1/20 0.40
EGLN1 Q9GZT9 1/20 0.40
ESR2 Q92731 1/20 0.40
XDH P47989 1/20 0.39
FFAR1 O14842 1/20 0.39
AKR1B1 P15121 1/20 0.39
MAPT P10636 1/20 0.39
SQOR Q9Y6N5 1/20 0.39
GSTO1 P78417 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
NLRP3 Q96P20 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylic Acid Ethyl Ester SCHEMBL28318010 0.93 ALDH1A1 (0.44) GRIA2GRIA4ALDH1A1KDM4EL3MBTL1
Benzoic Acid SCHEMBL5166939 0.84 ESR2 (0.49) GRIA2GRIA4EGLN1ESR2FFAR1
Benzoic Acid SCHEMBL3170966 0.83 AR (0.41) ALDH1A1L3MBTL1LMNAMAPTSMN1; SMN2
Benzoic Acid SCHEMBL28932601 0.82 MAPT (0.50) ALDH1A1LMNAGAAMAPTSMN1; SMN2
Benzoic Acid SCHEMBL28164446 0.81 MAPT (0.49) ALDH1A1LMNAMAPTSMN1; SMN2
Benzoic Acid SCHEMBL8919114 0.81 ESR2 (0.58) GRIA2GRIA4ESR2FFAR1AKR1B1
SCHEMBL28037124 0.81 TSHR (0.47) GRIA2GRIA4ALDH1A1KDM4EL3MBTL1
Acrylic Acid SCHEMBL211815 0.77 ESR2 (0.56) GRIA2GRIA4ALDH1A1KDM4EL3MBTL1
Biphenyl SCHEMBL17893027 0.76 THRB (0.53) ALDH1A1KDM4EL3MBTL1LMNAHPGD
SCHEMBL28084501 0.76 TSHR (0.59) GRIA2GRIA4ALDH1A1L3MBTL1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7153549-B2 Cholesteric liquid crystal additives 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-12-26 US claimed
US-20060124898-A1 Cholesteric liquid crystal additives 3M INNOVATIVE PROPERTIES COMPANY 2006-06-15 US claimed
US-7029729-B2 liquid crystal polymer and a non-liquid crystalline additive; optical displays that include the composition as a reflective polarizer, preferably haing no more than 10% absorption for transmission polarization over the wavelength desired 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-04-18 US claimed
EP-1601742-A1 CHOLESTERIC LIQUID CRYSTAL ADDITIVES 3M Innovative Properties Company (US) 2005-12-07 EP claimed
WO-2004076589-A1 CHOLESTERIC LIQUID CRYSTAL ADDITIVES 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-09-10 WO claimed
US-20040164275-A1 Cholesteric liquid crystal additives 3M INNOVATIVE PROPERTIES COMPANY 2004-08-26 US claimed
EP-1751589-B1 METHOD OF MANUFACTURE OF MULTILAYER CHOLESTERIC LIQUID CRYSTAL OPTICAL BODIES 3M INNOVATIVE PROPERTIES CO (US) 2010-08-04 EP disclosed
CN-100523126-C Cholesteric liquid crystal additives 3M INNOVATIVE PROPERTIES CO (US) 2009-08-05 CN disclosed
CN-100510002-C Cholesteric liquid crystal copolymers and additives 3M INNOVATIVE PROPERTIES CO (US) 2009-07-08 CN disclosed
US-7510741-B2 Method of making multilayer cholesteric liquid crystal optical bodies 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-03-31 US disclosed
EP-1660612-B1 CHOLESTERIC LIQUID CRYSTAL COPOLYMERS AND ADDITIVES 3M INNOVATIVE PROPERTIES CO (US) 2009-01-07 EP disclosed
EP-1599749-B1 METHODS OF MANUFACTURE OF CHOLESTERIC LIQUID CRYSTAL OPTICAL BODIES 3M INNOVATIVE PROPERTIES CO (US) 2007-10-31 EP disclosed
EP-1751589-A1 METHOD OF MANUFACTURE OF MULTILAYER CHOLESTERIC LIQUID CRYSTAL OPTICAL BODIES 3M Innovative Properties Company (US) 2007-02-14 EP disclosed
EP-1599749-A2 CHOLESTERIC LIQUID CRYSTAL OPTICAL BODIES AND METHODS OF MANUFACTURE AND USE 3M Innovative Properties Company (US) 2005-11-30 EP disclosed
WO-2005023964-A2 CHOLESTERIC LIQUID CRYSTAL COPOLYMERS AND ADDITIVES 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-03-17 WO disclosed
US-20050045854-A1 Cholesteric liquid crystal copolymers and additives 3M INNOVATIVE PROPERTIES COMPANY 2005-03-03 US disclosed
WO-2004076589-A1 CHOLESTERIC LIQUID CRYSTAL ADDITIVES 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-09-10 WO disclosed
WO-2004077106-A2 CHOLESTERIC LIQUID CRYSTAL OPTICAL BODIES AND METHODS OF MANUFACTURE AND USE 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-09-10 WO disclosed
US-20040164275-A1 Cholesteric liquid crystal additives 3M INNOVATIVE PROPERTIES COMPANY 2004-08-26 US disclosed
US-20040165140-A1 Cholesteric liquid crystal optical bodies and methods of manufacture and use 3M INNOVATIVE PROPERTIES COMPANY 2004-08-26 US disclosed