Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 8/20 | 0.60 |
| ▸ | PSMB5 | P28074 | 8/20 | 0.60 |
| ▸ | PSMB2 | P49721 | 6/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.59 |
| ▸ | LTA4H | P09960 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82435 | 0.79 | HRH3 (0.73) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| SCHEMBL13297167 | 0.79 | KDM4E (0.82) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| SCHEMBL3937460 | 0.79 | LTA4H (0.87) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| SCHEMBL14970684 | 0.79 | LTA4H (0.82) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| SCHEMBL12035585 | 0.79 | HRH3 (0.73) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| SCHEMBL23724061 | 0.79 | LTA4H (0.87) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| SCHEMBL15257179 | 0.79 | LTA4H (0.82) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| SCHEMBL3578646 | 0.79 | HRH3 (0.90) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| Hydrochloric Acid SCHEMBL14966283 | 0.78 | LTA4H (0.79) | PSMB1PSMB5PSMB2HRH3LTA4H | |
| Hydrochloric Acid SCHEMBL3997911 | 0.78 | LTA4H (0.84) | PSMB1PSMB5PSMB2HRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728032-B2 | Phenoxymethylalkyne inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2010-06-01 | — | — | US | disclosed |
| US-7728032-B2 | Phenoxymethylalkyne inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2010-06-01 | — | — | US | disclosed |
| US-20080090839-A1 | PHENOXYMETHYLALKYNE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2008-04-17 | — | — | US | disclosed |
| US-20080090839-A1 | PHENOXYMETHYLALKYNE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2008-04-17 | — | — | US | disclosed |
| WO-2008019284-A1 | PHENOXYMETHYLALKYNE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008019284-A1 | PHENOXYMETHYLALKYNE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090839-A1 | PHENOXYMETHYLALKYNE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTB4R, LTB4R2 | PSMB1 2492/4885PSMB5 1273/4885PSMB2 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.