Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24251673 | 0.90 | ALDH1A1 (0.44) | ALDH1A1MAPTHTTMAPK1KMT2A | |
| SCHEMBL28973016 | 0.86 | MAPT (0.39) | ALDH1A1MAPTMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL28510516 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL29133298 | 0.80 | WDR5 (0.43) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL27238331 | 0.80 | WDR5 (0.43) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL10745494 | 0.78 | POLB (0.49) | ALDH1A1MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL28973031 | 0.78 | MAPT (0.35) | ALDH1A1MAPTHTTMAPK1KMT2A | |
| SCHEMBL17490464 | 0.78 | NPSR1 (0.46) | ALDH1A1MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL28973029 | 0.77 | MCHR1 (0.38) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL28359061 | 0.76 | WDR5 (0.40) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115701429-B | 4- (1H-indol-1-yl) pyrimidine-2-amino derivative, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-115701429-A | 4- (1H-indole-1-yl) pyrimidine-2-amino derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-02-10 | — | — | CN | disclosed |