SCHEMBL28973809

SCHEMBL28973809

FC(CCCOCCCC(F)c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 6/20 0.38
HTR2A P28223 6/20 0.38
SIGMAR1 Q99720 2/20 0.34
KCNA3 P22001 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
ALDH1A1 P00352 1/20 0.33
SCN1A P35498 2/20 0.32
SCN2A Q99250 2/20 0.32
SCN3A Q9NY46 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32
ADRA2A P08913 1/20 0.32
CYP2D6 P10635 1/20 0.32
CHRM1 P11229 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7784138 0.80 HRH1 (0.58) HRH1HTR2ASIGMAR1TAAR1LMNA
SCHEMBL25361265 0.80 MEN1 (0.36) HRH1HTR2ASIGMAR1ALDH1A1MEN1
SCHEMBL28243790 0.78 HRH1 (0.46) HRH1HTR2ATAAR1TSHR
SCHEMBL27777636 0.77 ALDH1A1 (0.43) SMN1; SMN2ALDH1A1KMT2ALMNACYP1A2
SCHEMBL10846548 0.77 TRPA1 (0.41) HRH1HTR2ATAAR1ALDH1A1LMNA
SCHEMBL28044352 0.77 HRH1 (0.39) HRH1HTR2ASIGMAR1TAAR1LMNA
SCHEMBL6681384 0.77 POLB (0.45) HRH1HTR2ASIGMAR1ALDH1A1LMNA
SCHEMBL4890470 0.77 HRH1 (0.39) HRH1HTR2ASIGMAR1TAAR1TSHR
SCHEMBL16426377 0.77 HTR2A (0.39) HRH1HTR2ASIGMAR1TAAR1ALDH1A1
SCHEMBL5610591 0.77 HRH1 (0.44) HRH1HTR2ASIGMAR1TAAR1CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114716296-B Efficient halogenation synthesis method of alkyl halide 润药仁智(北京)科技有限公司 2023-12-12 CN disclosed
CN-114716296-A Efficient halogenation synthesis method of alkyl halide 北京大学 2022-07-08 CN disclosed