Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.32 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.32 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4177951 | 0.87 | KDM4E (0.39) | KDM4EPIM3DAPK3PRKD3MAP4K4 | |
| SCHEMBL28974193 | 0.84 | RET (0.33) | KDM1APARP1PARP2OPRM1TEAD1 | |
| SCHEMBL28976439 | 0.83 | PARP1 (0.31) | KDM1APARP1PARP2OPRM1TEAD1 | |
| SCHEMBL28976913 | 0.83 | PARP1 (0.31) | PARP1PARP2OPRM1TEAD1TEAD4 | |
| SCHEMBL30281182 | 0.83 | TEAD1 (0.34) | PARP1PARP2OPRM1TEAD1TEAD4 | |
| SCHEMBL30281265 | 0.76 | JAK2 (0.35) | KDM1APARP1PARP2OPRM1 | |
| SCHEMBL28976914 | 0.75 | KDM1A (0.31) | KDM1APARP1PARP2MAOB | |
| SCHEMBL28976466 | 0.72 | PARP1 (0.33) | KDM1APARP1PARP2OPRM1MAOB | |
| SCHEMBL28976948 | 0.70 | MAP3K14 (0.35) | KDM1APARP1PARP2OPRM1DYRK1A | |
| SCHEMBL28976927 | 0.70 | PARP1 (0.33) | KDM1APARP1PARP2OPRM1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115884810-A | Imidazopyridazines as IL-17 modulators | 詹森药业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-115867348-A | Imidazopyrimidines as IL-17 modulators | 詹森药业有限公司 | 2023-03-28 | — | — | CN | disclosed |