Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22014536 | 0.87 | TACR1 (0.48) | OPRK1MEN1KMT2AGPR119OPRD1 | |
| SCHEMBL22666983 | 0.86 | MAPT (0.62) | NAMPTMAPTMEN1KMT2AGPR119 | |
| SCHEMBL28974221 | 0.82 | GPR119 (0.46) | OPRK1GPR119OPRD1PKM | |
| SCHEMBL22660467 | 0.81 | NAMPT (0.57) | NAMPTOPRK1MAPTMEN1KMT2A | |
| SCHEMBL28528706 | 0.81 | P2RX7 (0.43) | GPR119HDAC1HDAC6PKMJAK2 | |
| SCHEMBL22770414 | 0.81 | POLB (0.46) | NAMPTOPRK1MEN1KMT2AGPR119 | |
| SCHEMBL23660647 | 0.80 | NAMPT (0.56) | NAMPTOPRK1MAPTMEN1KMT2A | |
| SCHEMBL25301984 | 0.80 | POLB (0.43) | NAMPTOPRK1GPR119OPRD1PKM | |
| SCHEMBL4326509 | 0.78 | LMNA (0.51) | OPRK1MEN1KMT2AOPRD1 | |
| SCHEMBL16049766 | 0.78 | NAMPT (0.59) | NAMPTOPRK1GPR119OPRD1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115974897-A | Bicyclic derivative-containing inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-112368283-B | Bicyclic derivative-containing inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-112368283-A | Bicyclic derivative-containing inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-02-12 | — | — | CN | disclosed |