Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28978309 | 0.99 | RIPK1 (0.60) | RIPK1HPGDALDH1A1KDM4EPOLB | |
| SCHEMBL4719174 | 0.80 | ALDH1A1 (0.58) | RIPK1HPGDALDH1A1KDM4EPOLB | |
| SCHEMBL28978282 | 0.79 | RIPK1 (0.83) | RIPK1ALDH1A1KDM4ECRBNDDB1 | |
| SCHEMBL28978300 | 0.77 | NPC1L1 (0.45) | RIPK1HPGDALDH1A1KDM4EPOLB | |
| SCHEMBL28978315 | 0.75 | NPC1L1 (0.44) | RIPK1HPGDALDH1A1KDM4EPOLB | |
| SCHEMBL28978314 | 0.74 | RIPK1 (0.72) | RIPK1CHRM2CHRM3 | |
| SCHEMBL28978316 | 0.74 | RIPK1 (0.79) | RIPK1ALDH1A1KDM4ECRBNDDB1 | |
| SCHEMBL28978285 | 0.74 | RIPK1 (1.00) | RIPK1ALDH1A1KDM4EPOLBCRBN | |
| SCHEMBL28978328 | 0.73 | RIPK1 (0.71) | RIPK1ALDH1A1CRBNDDB1USP2 | |
| SCHEMBL30289705 | 0.73 | RIPK1 (0.64) | RIPK1HPGDALDH1A1KDM4ECRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894489-A | Inhibitor of receptor interaction protein kinase 1, preparation method and application thereof | 中国药科大学 | 2023-04-04 | — | — | CN | disclosed |