Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 3/20 | 0.70 |
| ▸ | BRD4 | O60885 | 11/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | BTK | Q06187 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31260251 | 1.00 | MAP3K7 (0.70) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL31684797 | 0.91 | BRD4 (0.66) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL28981000 | 0.91 | BRD4 (0.66) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL28980987 | 0.87 | BRD4 (0.77) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL31684795 | 0.87 | BRD4 (0.77) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL28980969 | 0.83 | BRD4 (0.64) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL31684801 | 0.83 | BRD4 (0.64) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL31684799 | 0.83 | MAP3K7 (0.72) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL28980964 | 0.83 | MAP3K7 (0.72) | MAP3K7BRD4FLT3BTKEGFR | |
| SCHEMBL31684777 | 0.81 | MAP3K7 (0.80) | MAP3K7BRD4FLT3BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | disclosed |